Swine Health - PRRS
Determine the mechanisms of cross-protection against infection with a divergent porcine reproductive and respiratory virus strain
December 11, 2015By Hiep Vu
PRRS modified live virus (MLV) vaccines have been licensed for clinical administration for over 20 years. The vaccines confer solid protection against homologous PRRSV strains. However, the extent...
Swine Health - PRRS
Development of next generation sequencing methodology for full genome characterization of porcine reproductive and respiratory syndrome virus (PRRSV) from oral fluids and nasal swabs
September 23, 2015By Ben Hause
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most significant swine diseases with near worldwide distribution. In the U.S., open reading frame 5 (ORF5) is commonly...
Swine Health - PRRS
The contribution of adaptive immunity to Porcine Reproductive and Respiratory Syndrome virus infection
January 5, 2015By Melinda Wilkerson
Objectives: The purpose of our studies was to understand how adaptive immunity contributes to the susceptibility of nursery-age piglets to...
Swine Health - PRRS
Development of PRRS virus-like-particles containing nanoparticle vaccine and its evaluation in pigs
December 1, 2014By Renukaradhya Gourapura
Porcine Reproductive and Respiratory Syndrome (PRRS) is a chronic and economically important viral disease of pigs. Currently used PRRS virus (PRRSV) vaccines have failed to completely protect...
Swine Health - PRRS
Rational design of a broadly protective vaccine against porcine reproductive and respiratory syndrome virus
November 14, 2014By Hiep Vu
Current PRRS vaccines are not adequately effective for control and eradication of PRRS. The main limitation of the current PRRS vaccines is their sub-optimal coverage against divergent PRRSV strains...
Swine Health - PRRS
Defining a Novel Structural Component of Porcine Reproductive and Respiratory Syndrome Virus and its Role in Disease Pathogenesis
November 13, 2014By Kay S. Faaberg
The objective of this project was to characterize the makeup of nsp2, shown to be a new structural component of the PRRSV virion. Radiolabelled nsp2 protein, in the absence or presence of...
Swine Health - PRRS
Further development of an integrated mapping service to support regional control & elimination of PRRS virus
October 1, 2014By Robert B. Morrison
There are approximately 20 regional PRRS projects in the United States in various stages of progress. Each coordinator has their own approach to the challenges of mapping the region, many depending...
Swine Health - PRRS
Impact of pig farm density on incidence of PRRS in a cohort of sow herds
October 1, 2014By Robert B. Morrison
This project was designed to measure the incidence of PRRS infection in a cohort of US sow herds. Additionally, it sought to conduct a risk assessment based on the density of swine farms around...
Swine Health - PRRS
Viral structural components that enable vaccine-induced protective immunity against contemporary high morbidity and high mortality PRRS virus
September 18, 2014By Federico A. Zuckermann
The production of interferon (IFN)- by an animal in response to a viral infection is known to be a principal determinant of the animal’s ability to fight the infection. In addition, this...
Swine Health - PRRS
PRRS Immunology Literature Review
July 16, 2014By Crystal Loving
PRRSV infection is a chronic infection, persisting in an animal for months. While the early stages of disease are associated with virus in the blood, that virus is eventually cleared; however,...
