The results of this study document that sodium chlorate / nitrate / lactate, used alone or combination with early weaning and/or topical disinfection can be effective in reducing Salmonella concentration in feces and cecal content and in reducing Salmonella prevalence in feces and ileocecal lymph nodes. Since the compound has low toxicity and can be applied to pigs of differing ages, these findings suggest that chlorate should be considered as a preharvest intervention to reduce Salmonella shedding in swine. The treatment was ineffective in breaking the cycle of transmission at weaning, even when done in combination with other treatments. The Salmonella reduction was prolonged through the 9 days of follow-up testing. This may allow for increased flexibility in the application of chlorate as a pre-harvest intervention. In sum, topical disinfection and CHLORATE may be useful tools for farms that practice segregated weaning, and where sow to piglet transfer of Salmonella is an important source of infection in nursery pigs. However, this would be effective as a food safety intervention if and only if the duration of protection is sustained through the growing period, a question that was not addressed in the current study.