Swine Health - Foreign Animal Disease
Mass Composting of Swine Slurry
This project will address several concerns related to composting slurry/manure.
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Swine Health - Foreign Animal Disease
Evaluation of Lyophilization on Efficacy of African Swine Fever Vaccine Candidate ASFV-G-DI177L
This study was to evaluate the ability of the vaccine to be lyophilized, and the stability of the vaccine under different storage conditions.
Swine Health - Foreign Animal Disease
Investigating the Use of Novel Antemortem and Postmortem Sample Types for Detection of African Swine Fever Virus Infection after Natural Consumption
Overall, this study provides data on novel diagnostic sample types in a unique natural consumption model with potential benefits towards enhanced surveillance and early ASFV detection.
Swine Health - Foreign Animal Disease
Systematic Discovery of ASFV Determinants of Virulence to Improve the Safety Profile of First Generation Live-Attenuated ASFV Vaccines
In this study we aimed to identify proteins in ASFV using serum containing antibodies from animals with live-attenuated vaccinated animals, that could be used as targets for a serological assay to differentiate between vaccinated and infected animals, these identified proteins were attempted to be deleted from a field isolate of highly pathogenic ASFV, to determine if they could be deleted.
Swine Health - Foreign Animal Disease
A Literature Review to Gather the Scientific Data Required for an African Swine Fever Virus (ASFv) Exposure Assessment of US Domestic Pigs Raised in Total Confinement and/or Without Door Access to ASFv-Infected Feral Swine
The purpose of this literature review was to identify the pathways by which feral swine might transmit ASFV to domestic pigs in the US.
Swine Health - Foreign Animal Disease
An Enzyme Linked Immunoassay (ELISA) to Detect Classical Swine Fever Antibodies and to Differentiate Infected from Vaccinated Animals (DIVA)
This project addresses the need to develop and validate a CSF diagnostic test with DIVA capabilities, and improving specificity and sensitivity compared to current methods.
Swine Health - Foreign Animal Disease
Developing Best Practice Recommendations for Transporting Ingredients or Feed during a Foreign Animal Disease Outbreak
The objectives of this review are to describe the current knowledge of ASFV survival in raw materials used to produce porcine-based ingredients, identify priorities for future research, and summarize potential options for managing risk until additional knowledge can be gained.
Swine Health - Foreign Animal Disease
Swine Bioassay to Determine Sample Infectivity for Decontamination of Interior Surfaces (cabs) of Transportation Vehicles
The objective of this project was to evaluate commercially available disinfectants and disinfection application methods against PEDV and PRRSV on various surfaces within semi-truck cabs including assessment of viral infectivity using a swine bioassay model.
Swine Health
Classical Swine Fever PCR Negative Cohort Study
Partnering to expand testing capacities, support further evaluation and validation of two commercially available CSF PCR assays, and enhance preparedness across the NAHLN.
Swine Health
Assessing the feasibility of the mRNA vaccine technology for use against ASF
In this study, we aim to explore the potential of mRNA vaccine technology for the development of a subunit vaccine against ASFV. For this pilot project, we focused on assessing the immunogenicity of mRNA vaccines containing four well-characterized ASFV antigens: p32, p54, C-type lectin, and CD2v. Each of these antigens plays a distinct role in the viral lifecycle.
