Scientific Abstract
Background
Porcine epidemic diarrhea virus (PEDV) is a highly contagious enteric coronavirus that has caused severe economic losses in the swine industry worldwide. The virus spreads rapidly through fecal-oral transmission and contaminated fomites. Despite extensive research on vaccines, biosecurity, and inactivation strategies, PEDV remains endemic. This systematic review evaluates the key epidemiological factors relevant to the feasibility of PEDV eradication.
Methods
A systematic review of peer-reviewed literature published since 1990 was conducted using multiple bibliographic databases. Studies were selected based on their relevance to PEDV transmission, biosecurity interventions, and disease control measures, including vaccination, antiviral strategies, epidemiological modeling, and inactivation methods. Data from eligible studies were synthesized to provide an overview of current knowledge and gaps.
Results
The review identified key risk factors including viral shedding duration, transportation-related contamination, and feed-based transmission, all of which complicate eradication efforts. Epidemiological modeling suggests that localized control measures can reduce outbreaks, but national-level eradication remains challenging. Biosecurity measures, heat inactivation, and chemical disinfectants are helpful adjuncts to controlling viral spread but transportation networks remain a weak point in PEDV containment.
