PRRSV, M. hyopneumoniae, influenza, PCV2, and other endemic pathogens continue to cause significant economic losses to U.S. swine producers. In part, the disease status quo is maintained by the absence of timely information on the circulation of pathogens. Already a proven technology in human diagnostic medicine, oral fluid-based testing could facilitate monitoring of disease in animal populations. Availability of disease data would facilitate (1) appropriately timed and targeted interventions; (2) “real time” evaluations of interventions; and (3) accurate estimates of the impact of specific pathogens on pig health and productivity.