The present study consisted of two trials. In Trial 1 we tested the effectiveness of the NPCB on 100 suckling piglets that were less than 3 days of age (average weight 1.04 kg ± 0.03 SE) using reflexes that indicate signs of consciousness, duration of neuromuscular spasms (leg paddling) and time to cardiac arrest. We also determined the degree of brain damage by macroscopic scoring of damage at gross necropsy, and by CT scans performed by a veterinary radiologist and microscopic examinations of the brain by a veterinary pathologist on a sample of piglets. Ten stock people (10 piglets each) from 4 different farms performed the euthanasia.
All 100 piglets were immediately rendered insensible without return to consciousness. On average, leg movements ceased in 229 sec (± 9.2 SE). Only five piglets (5%) required a secondary step due to prolonged presence of a heartbeat; all other piglets reached full cardiac arrest in 444 sec (± 18.7 SE). From CT scans, skull fracture displacement averaged 6.2 mm (± 0.07 SE) and severe hemorrhage was reported in 50% of the piglets scored. From macroscopic scoring, moderate to severe damage was found in all piglets. Microscopic analysis reported moderate hemorrhage on the brain surface in 70% of the piglets scored as well as moderate hemorrhage within the brain tissue in 50% of the piglets scored. These results indicated that method was highly effective for euthanasia of the neonate piglets and that its effectiveness on larger weight classes should be investigated.
Comparisons between the neonatal and larger anesthetized piglets indicated that duration of leg spasms was significantly shorter in the larger anaesthetized piglets (p< .001); but time to full cardiac arrest was not different. Results of CT scans and microscopic scoring indicated that brain hemorrhage was significantly less severe in the larger, anaesthetized piglets but that skull fracture displacement was significantly greater (p=.019).
The results form Trial 2 indicated that the NPCB can effectively induce cardiac arrest in piglets up to 9 kg and that it caused brain lesions known to be associated with loss of consciousness in Trial 1. The next stage of research will be testing the effectiveness of the NPCB on conscious piglets. Due to the size of the piglets within the next trial (up to 9 kg), a restraint device will also be designed to ensure the safety of the operator and the piglet.