Swine Health - General Disease
A candidate swine influenza virus vaccine: in vivo evaluation of novel chimeric hemagglutinins expressed by parainfluenza virus 5 (PIV5) vector
December 1, 2016By Victor Huber
The goal of this project was to evaluate candidate influenza vaccines that induce broad immunity against multiple influenza viruses in pigs. These vaccines have been designed to induce immune...
Development of swine influenza virus platform vector vaccines to control swine influenza virus and porcine epidemic diarrhea virus
June 28, 2016By Ben Hause
Influenza A virus (IAV) causes significant losses to the swine industry. Here we constructed a novel attenuated live IAV vaccine designed to elicit an immune response to conserved IAV proteins by...
Swine Health - General Disease
Live-animal assay for identifying correlates of cross-protection for swine influenza virus vaccines when vaccinated in the presence of maternal antibody.
June 21, 2016By Crystal Loving
Experimental live-attenuated influenza virus (LAIV) vaccines, delivered into the nose, have been shown protect pigs against influenza infection, more so than traditional inactivated commercial...
Public Health - Influenza
Epidemiological surveillance of influenza A viruses in pigs entering swine exhibitions
December 1, 2015By Andrew Bowman
Swine play a key role in the evolution and ecology of influenza A virus (IAV) infecting humans as pigs are a host species in which reassortment of the IAV segmented genome commonly occurs. Due to the...
Swine Health - General Disease
Evaluation of two novel live attenuated swine influenza vaccines against newly emerging H3N2 virus infection and transmission
July 7, 2015By Yan Zhou
After the 2009 pandemic, variant H3N2 swine influenza viruses (H3N2v SIV) carrying genes from pandemic H1N1 emerged in pig farms. The objective of this study is to investigate whether the two live...
Swine Health - General Disease
Live-animal assay for identifying correlates of protection/cross-protection for intranasal swine influenza virus vaccines
April 14, 2015By Crystal Loving
The majority of vaccines currently available for the prevention of influenza A virus (IAV) in swine are formulated as whole-inactivated...
Swine Health - General Disease
Advances in Vaccine Design: Developing A Cross-conserved Influenza Vaccine for Swine
July 28, 2014By Anne De Groot
The overall goal of this project was to implement the innovative iVAX suite of immunoinformatics vaccine design tools that have been extensively validated in pre-clinical studies of human...
Public Health - Influenza
Determining viral load and persistence of influenza A in aerosols and on surfaces of swine production facilities
July 11, 2014By Peter Rabinowitz
Although influenza A is capable of significant impacts in swine production, including the possibility of transmission between pigs and people, little is known of the exposure risks for viral...
Swine Health - General Disease
Detection and characterization of influenza A virus endemic circulation in neonatal and nursery pigs in a farm using routine influenza vaccination
April 8, 2014By Phil Gauger
Swine influenza virus is the cause of an acute respiratory disease affecting swine worldwide. Inactivated influenza vaccines used in breeding females provides passive immunity to neonatal...
Swine Health - General Disease
Development of novel mucosal vaccines against swine influenza in pigs
January 6, 2014By Mahesh Khatri
Swine influenza is a highly contagious acute respiratory viral disease of swine. The causative agent swine influenza virus (SIV) has been widely prevalent in the US swineherds. Control of influenza...
Swine Health - General Disease
Generating swine influenza virus (SIV) oral fluid diagnostic Reference Standards for community use
November 4, 2013By Jeffrey Zimmerman
Influenza A virus is an important component of the porcine respiratory disease complex (Thacker et al., 2001) and a pathogen with a major economic impact on swine production. Holtkamp (2007a,b)...
Swine Health - General Disease
Evaluation of novel reassortant swine influenza viruses
July 1, 2013By Wenjun Ma
Since the 2009 pandemic H1N1 virus (pH1N1) was found to transmit to pigs worldwide including in the USA, subsequent reassortment events between pH1N1 and endemic swine influenza viruses (SIVs)...
